Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug
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چکیده
منابع مشابه
Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug.
In human epilepsy, pharmacoresistance to antiepileptic drug therapy is a major problem affecting a substantial fraction of patients. Many of the currently available antiepileptic drugs target voltage-gated sodium channels, leading to a rate-dependent suppression of neuronal discharge. A loss of use-dependent block has emerged as a potential cellular mechanism of pharmacoresistance for anticonvu...
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ژورنال
عنوان ژورنال: Brain
سال: 2014
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awu339